The Science of HIV/AIDS

What is it, and are we close to a cure? SHARE on Twitter: http://bit.ly/1NalHm8 & Facebook: http://on.fb.me/1MTLpMp Get a FREE Audible Trial: http://audible.com/asap Written by Rachel Salt, Mitchell Moffit and Gregory Brown SUBSCRIBE for more (it s free!): http://bit.ly/asapsci GET THE ASAPSCIENCE BOOK: http://asapscience.com/book/ FOLLOW US! Instagram and Twitter: @whalewatchmeplz and @mitchellmoffit Clickable: http://bit.ly/16F1jeC and http://bit.ly/15J7ube AsapINSTAGRAM: https://instagram.com/asapscience/ Facebook: http://facebook.com/AsapSCIENCE Twitter: http://twitter.com/AsapSCIENCE Tumblr: http://asapscience.tumblr.com Vine: Search "AsapSCIENCE" on vine! SNAPCHAT whalewatchmeplz and pixelmitch Created by Mitchell Moffit (twitter @mitchellmoffit) and Gregory Brown (twitter @whalewatchmeplz). Send us stuff! ASAPSCIENCE INC. P.O. Box 93, Toronto P Toronto, ON, M5S2S6 Further Reading: https://www.aids.gov/hiv-aids-basics/hiv-aids-101/global-statistics/ The Global HIV/AIDS Epidemic HIV Transmission http://www.cdc.gov/hiv/basics/transmission.html http://lcbb4.epfl.ch/reading/HIV/2013-PeetersOriginEpidemiologyHIV.pdf The origin and molecular epidemiology of HIV https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2441482/ Env length and N-linked glycosylation following transmission of Human Immunodeficiency Virus Type 1 subtype B viruses http://www.researchgate.net/profile/Pavel_Pugach/publication/8679190_The_CCR5_and_CXCR4_coreceptors--central_to_understanding_the_transmission_and_pathogenesis_of_human_immunodeficiency_virus_type_1_infection/links/0fcfd51200b440c2fe000000.pdf The CCR5 and CXCR4 coreceptors-central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection. AIDS Res. Hum. Retroviruses 20, 111-126 http://dspace.uah.es/dspace/bitstream/handle/10017/5071/840.pdf?sequence=1 Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes? http://www.biomedcentral.com/content/pdf/1742-4690-6-40.pdf A historical reflection on the discovery of human retroviruses http://www.ms.uky.edu/~ma137/Fasttrack13/HIV_Perelson_Science1996.pdf HIV-1 Dynamics in Vivo: Virion Clearance Rate, Infected Cell Life-Span, and Viral Generation Time Precise determination of time to reach viral load set point after acute HIV-1 infection. http://www.ncbi.nlm.nih.gov/pubmed/23143525 http://www.nature.com/nature/journal/v362/n6418/abs/362355a0.html HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease http://www.joponline.org/doi/abs/10.1902/jop.1994.65.5.393 Necrotizing Ulcerative Periodontitis: A Marker for Immune Deterioration and a Predictor for the Diagnosis of AIDS https://www.aids.gov/hiv-aids-basics/just-diagnosed-with-hiv-aids/hiv-in-your-body/stages-of-hiv/ Stages of HIV Infection http://www.cdc.gov/hiv/basics/livingwithhiv/opportunisticinfections.html Opportunistic Infections https://aidsinfo.nih.gov/drugs/445/pyrimethamine/0/patient AIDSinfo Drug Database http://www.cdc.gov/hiv/basics/prep.html PrEP http://www.who.int/hiv/topics/mtct/q2_chi_2007.pdf Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial http://dspace.uah.es/dspace/bitstream/handle/10017/5071/840.pdf?sequence=1 Dimerization inhibitors of HIV-1 reverse transcriptase, protease and integrase: A single mode of inhibition for the three HIV enzymes? http://lcbb4.epfl.ch/reading/HIV/2013-PeetersOriginEpidemiologyHIV.pdf http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234451/ http://www.nejm.org/doi/full/10.1056/NEJMoa0802905 Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation