An Alzheimer’s Drug That Doesn’t Treat Alzheimer’s?

Head to https://linode.com/scishow to get a $100 60-day credit on a new Linode account. Linode offers simple, affordable, and accessible Linux cloud solutions and services. In 2021, the FDA approved a treatment that claims to stop Alzheimer's at the source, removing the plaques in the brain long thought to cause the symptoms of the disease. But, as is often the case, things are more complicated than they first appear. Hosted by: Michael Aranda SciShow is on TikTok! Check us out at https://www.tiktok.com/@scishow ---------- Support SciShow by becoming a patron on Patreon: https://www.patreon.com/scishow ---------- Huge thanks go to the following Patreon supporters for helping us keep SciShow free for everyone forever: Tomás Lagos González, Sam Lutfi. Bryan Cloer, Christoph Schwanke, Kevin Bealer, Jacob, Jason A Saslow, Nazara, Tom Mosner, Ash, Eric Jensen, Jeffrey Mckishen, Matt Curls, Alex Hackman, Christopher R Boucher, Piya Shedden, Jeremy Mysliwiec, charles george, Chris Peters, Adam Brainard, Dr. Melvin Sanicas, Harrison Mills, Silas Emrys, Alisa Sherbow ---------- Looking for SciShow elsewhere on the internet? SciShow Tangents Podcast: https://scishow-tangents.simplecast.com/ Facebook: http://www.facebook.com/scishow Twitter: http://www.twitter.com/scishow Instagram: http://instagram.com/thescishow #SciShow ---------- Sources: https://www.health.harvard.edu/blog/a-new-alzheimers-drug-has-been-approved-but-should-you-take-it-202106082483 https://www.fda.gov/news-events/press-announcements/fda-grants-accelerated-approval-alzheimers-drug https://pubmed.ncbi.nlm.nih.gov/12130773/ https://www.statnews.com/2016/11/14/alzheimers-brain-amyloid-plaque/ https://www.science.org/doi/10.1126/science.1566067 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174086/ https://www.science.org/doi/pdf/10.1126/science.2933807 https://www.bmj.com/content/372/bmj.n156 https://www.nature.com/articles/d41586-021-01546-2 https://www.neurologylive.com/view/aducanumab-phase-4-real-world-observational-study-announced https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278466/ https://pubmed.ncbi.nlm.nih.gov/9189035/ https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12213 https://www.orthopeden.org/downloads/242/Standardizing%20Patient%20Outcomes%20Measurement.pdf https://jamanetwork.com/journals/jamaneurology/fullarticle/1107509 https://www.biopharma-reporter.com/Article/2021/12/20/Aducanumab-rejected-in-the-EU-Biogen-will-ask-EMA-to-re-examine-application https://www.sciencedirect.com/topics/neuroscience/tau-protein https://www.alz.org/media/Documents/alzheimers-dementia-tau-ts.pdf https://pubmed.ncbi.nlm.nih.gov/9386780/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560290/ https://youtu.be/E6PgRD-CsYo?t=795 https://youtu.be/E6PgRD-CsYo?t=1908 https://youtu.be/E6PgRD-CsYo?t=625 https://www.brightfocus.org/alzheimers/article/tau-protein-and-alzheimers-disease-whats-connection https://www.lexico.com/en/definition/glia https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394397/ https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(21)00067-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2162253121000676%3Fshowall%3Dtrue https://www.alzheimersresearchuk.org/tackling-tau-scientists-find-local-spread-is-how-alzheimers-progresses/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713404/ https://www.jbc.org/article/S0021-9258(20)47639-2/fulltext https://pubmed.ncbi.nlm.nih.gov/29053874/ Images: https://commons.wikimedia.org/wiki/File:Amyloid_03big1.jpg https://commons.wikimedia.org/wiki/File:Beta-Amyloid_Plaques_and_Tau_in_the_Brain_(38686503251).png https://en.wikipedia.org/wiki/File:APP_processing.png https://commons.wikimedia.org/wiki/File:Astrocytes_surrounding_amyloid_plaques_III.tif https://commons.wikimedia.org/wiki/File:Alzheimers_Disease.jpg https://commons.wikimedia.org/wiki/File:Entorhinal_-_DK_ATLAS.png https://commons.wikimedia.org/wiki/File:Gray739-emphasizing-hippocampus.png https://commons.wikimedia.org/wiki/File:Neurofibrillary_tangles_in_the_Hippocampus_of_an_old_person_with_Alzheimer-related_pathology,_HE_1.JPG https://commons.wikimedia.org/wiki/File:Brain-derived_neurotrophic_factor_-_PDB_id_1BND.png https://www.frontiersin.org/articles/10.3389/fnins.2019.01274/full